Week 10 · Preview

49ers vs. Cowboys: Week 10 preview

SF49ers7-1

DALCowboys4-5

Sun, Nov 15 · 3:25 p.m. CT · Fox · AT&T Stadium

Line SF -3.5, total 55.5

63.8%35.9%

ESPN win chance · SF left, DAL right

Forecast49°F, gusts 21 mph (ESPN/AccuWeather)

Key storylines

The 49ers (7-1) visit the Cowboys (4-5) in Week 10.

Form check: the 49ers are on a 1-game winning streak and sit first in the NFC West. The Cowboys are on a 1-game winning streak and are 2nd in the NFC East.

Brandon Aiyuk is on an unpaid roster exemption that runs through Nov. 23, and Matt Maiocco of NBC Sports Bay Area says the 49ers are likely to keep him until it expires (49ers Webzone, Nov 10).

Matchups that decide it

Scoring matchup: the 49ers offense ranks 3rd in points per game; the Cowboys defense ranks 25th (tied) in points allowed.
Other side of the ball: the Cowboys offense ranks 6th in scoring, against a 49ers defense that ranks 6th in points allowed.
49ers injuries: Brandon Aiyuk (out, personal), C.J. West (injured reserve, knee), and Gracen Halton (injured reserve, ankle).
Quarterbacks this season: Brock Purdy is 163 of 236 for 1,980 yards, 17 TDs and 5 INTs; Dak Prescott is 218 of 336 for 2,381 yards, 16 TDs and 5 INTs.

49ers injuries

1 out8 questionable2 injured reserve

Brandon AiyukWR
Out
personal
Mike EvansWR
QuestionableStarter · WR1Tracked contract
right achilles
Trent WilliamsOT
QuestionableStarter · LTTracked contract
shoulder
Deommodore LenoirCB
QuestionableStarter · RCB
foot
Dre GreenlawLB
QuestionableStarter · WLB
knee

See all 11 on the injury report

Cowboys injuries

3 out7 questionable2 injured reserve

Jake FergusonTE
OutStarter · TETracked contract
knee
P.J. LockeS
OutStarter · SS
concussion
Tyler GoodsonRB
Out
knee (ACL + MCL)
George PickensWR
QuestionableStarter · WR2Tracked contract
hamstring
Donovan EzeiruakuLB
QuestionableStarter · SLB
ankle

See all 12 on the injury report

Season leaders

SF 49ers

Passing YardsBrock Purdy163/236, 1,980 YDS, 17 TD, 5 INT
Rushing YardsChristian McCaffrey102 CAR, 457 YDS, 9 TD
Receiving YardsGeorge Kittle38 REC, 483 YDS, 5 TD
SacksKeion White3.5

DAL Cowboys

Passing YardsDak Prescott218/336, 2,381 YDS, 16 TD, 5 INT
Rushing YardsJavonte Williams154 CAR, 629 YDS, 9 TD
Receiving YardsCeeDee Lamb70 REC, 904 YDS, 7 TD
SacksQuinnen Williams5

Referee assignment

Week: 10
Game: 49ers at Cowboys
Referee: Bill Vinovich
Kickoff: Sun, Nov 15, 3:25 p.m. CT

Crew penalty rates are coming soon. Public trackers disagree on them, so we are not printing a number yet.

Source: Football Zebras, Week 10 referee assignments, as of 2026-11-13.

Who's favored

ESPN win chance63.8%49ers

LineSF -3.5Total 55.5

Both ESPN's predictor and the line lean 49ers.

We don't make our own pick. These are ESPN's and the sportsbook's published numbers.

What is the win chance?

ESPN's matchup predictor, built on its Football Power Index. It simulates the game many times, and the percentage is how often each team wins. It is ESPN's number, not ours.

How do I read the line?

The point spread from a sportsbook. "GB -3" means the Packers are expected to win by about 3 points. The total (over/under) is the expected combined score of both teams.

The Fan GM Weekly

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Data note: scores, schedules, standings, injuries, lines, and ESPN's predictor come from ESPN's public APIs, as of Nov 13, 2026, 10:46 a.m. CT. Deadline and roster notes in previews and 60-second reads come from official announcements and cited reporting. Other written text is generated from the ESPN data and adds no numbers of its own.