Week 10 · Preview
Cowboys vs. 49ers: Week 10 preview
Line SF -3.5, total 55.5
ESPN win chance · SF left, DAL right
Key storylines
The Cowboys (4-5) host the 49ers (7-1) in Week 10.
Form check: the Cowboys are on a 1-game winning streak and sit 2nd in the NFC East, 1.5 games behind the Giants. The 49ers are on a 1-game winning streak and are 1st in the NFC West.
Rookie Caleb Downs sealed the 27-23 win at Indianapolis, which got Dallas to 4-5 heading into Sunday's home game against San Francisco.
The injury list is long again. Jake Ferguson and Tyler Goodson are out for 'multiple weeks' with knee injuries, and P.J. Locke was ruled out for the 49ers game after his second concussion in two weeks.
DeMarvion Overshown was a full participant Thursday and is in line to return. George Pickens (hamstring) and KaVontae Turpin (ribs) were limited. Joey Porter Jr. (ankle) didn't practice Wednesday or Thursday but hopes to play.
Dallas stood pat at the trade deadline. After the year's earlier trades, the Cowboys hold only four 2027 draft picks.
Matchups that decide it
- Scoring matchup: the Cowboys offense ranks 6th in points per game; the 49ers defense ranks 6th in points allowed.
- Other side of the ball: the 49ers offense ranks 3rd in scoring, against a Cowboys defense that ranks 25th (tied) in points allowed.
- 49ers injuries: Brandon Aiyuk (out), C.J. West (injured reserve), and Gracen Halton (injured reserve).
- Quarterbacks this season: Dak Prescott is 218 of 336 for 2,381 yards, 16 TDs and 5 INTs; Brock Purdy is 163 of 236 for 1,980 yards, 17 TDs and 5 INTs.
Cowboys injuries
- Jake FergusonTEOutStarter · TETracked contract
knee
- P.J. LockeSOutStarter · SS
concussion
- Tyler GoodsonRBOut
knee (ACL + MCL)
- George PickensWRQuestionableStarter · WR2Tracked contract
hamstring
- Donovan EzeiruakuLBQuestionableStarter · SLB
ankle
49ers injuries
- Brandon AiyukWROut
personal
- Mike EvansWRQuestionableStarter · WR1Tracked contract
right achilles
- Trent WilliamsOTQuestionableStarter · LTTracked contract
shoulder
- Deommodore LenoirCBQuestionableStarter · RCB
foot
- Dre GreenlawLBQuestionableStarter · WLB
knee
Season leaders
DAL Cowboys
- Passing YardsDak Prescott218/336, 2,381 YDS, 16 TD, 5 INT
- Rushing YardsJavonte Williams154 CAR, 629 YDS, 9 TD
- Receiving YardsCeeDee Lamb70 REC, 904 YDS, 7 TD
- SacksQuinnen Williams5
SF 49ers
- Passing YardsBrock Purdy163/236, 1,980 YDS, 17 TD, 5 INT
- Rushing YardsChristian McCaffrey102 CAR, 457 YDS, 9 TD
- Receiving YardsGeorge Kittle38 REC, 483 YDS, 5 TD
- SacksKeion White3.5
Referee assignment
- Week
- 10
- Game
- 49ers at Cowboys
- Referee
- Bill Vinovich
- Kickoff
- Sun, Nov 15, 3:25 p.m. CT
Crew penalty rates are coming soon. Public trackers disagree on them, so we are not printing a number yet.
Source: Football Zebras, Week 10 referee assignments, as of 2026-11-13.
Who's favored
Both ESPN's predictor and the line lean 49ers.
We don't make our own pick. These are ESPN's and the sportsbook's published numbers.
What is the win chance?
ESPN's matchup predictor, built on its Football Power Index. It simulates the game many times, and the percentage is how often each team wins. It is ESPN's number, not ours.
How do I read the line?
The point spread from a sportsbook. "GB -3" means the Packers are expected to win by about 3 points. The total (over/under) is the expected combined score of both teams.
The Fan GM Weekly
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Data note: scores, schedules, standings, injuries, lines, and ESPN's predictor come from ESPN's public APIs, as of Nov 13, 2026, 10:46 a.m. CT. Deadline and roster notes in previews and 60-second reads come from official announcements and cited reporting. Other written text is generated from the ESPN data and adds no numbers of its own.